In this study led by Dr Bassam Janji and his collaborators in the Tumor Immunotherapy and Microenvironment group of LIH, we are using multi-parametric MRI to evaluate the impact of cancer immunotherapy treatment on tumor hypoxic status and tumor vascular integrity of childhood neuroblastoma.  Using an appropriate neuroblastoma mouse model, we seek to establish how relaxometry and perfusion MRI protocols can be used to monitor therapy-dependent tumor vascular integrity and hypoxia changes, thus providing surrogate imaging markers of the treatment efficacy.