Multi-modal Imaging of Brain Tumors

For many years, we have collaborated with the Norlux Laboratory of Neuro-Oncology of Pr Simone Niclou at LIH, and with Pr Rolf Bjerkvig & Pr Frits Thorsen from the University of Bergen, to establish multi-parametric protocols for the imaging of brain tumors. Anatomical, physiological and spectroscopic images are used to provide insight into the development of brain tumors and the impact of experimental therapies1.

In a study to assess the physiologic changes induced by anti-angiogenic therapies on glioblastoma2, we used DCE-MRI based perfusion imaging, and diffusion imaging correlated to histology, to show that bevacizumab reduces blood supply to the tumor and increases infiltration of tumor cells.

In a follow-up study focusing on the changes induced in the early stages of the therapy3, we combined multi-parametric MRI with PET to show that the morphological normalization of the tumor vasculature and associated increase in hypoxia did not result in a functional normalization of the vessels that would have been useful to improve the delivery of drugs to the tumor.

 

1. Keunen et al., Adv Drug Deliv Rev. 2014 Sep 30;76:98-115. doi: 10.1016/j.addr.2014.07.010. (Pubmed)
2. Keunen et al., Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3749-54. doi: 10.1073/pnas.1014480108. (Pubmed)
3. Obad et al., J Cereb Blood Flow Metab. 2018 Oct;38(10):1741-1753. doi: 10.1177/0271678X17714656. (Pubmed)